Education


  • Biopharmaceutics and Pharmacokinetics
    • Course Introduction
    • This is for undergraduate and 6-year program (Bachelor’s and Master’s degree liaison) students, which gives 2 credits, opens in the first semester of every school year, total 36 hours.

      Aim: To learn and understand Pharmacokinetics, Population Pharmacokinetics, the Theory and Application of PK/PD Modeling and Simulation, and their application in Drug Research and Development and Clinical Pharmacology.

      Require preparatory courses: Anatomy, Physiology, Biochemistry, Pharmacology, Pharmaceutics, Higher Mathematics, Calculus and Statistics.

      Note: As a compulsory course for the students majoring in pharmaceutics, it is composed of biopharmaceutics and pharmacokinetics.

      Aided by different kinds of mathematic models, pharmacokinetics quantitatively describes the drug behaviors within the body. The basic concepts of compartmental model, non-linear compartment model (NLPK), non-compartmental analysis (NCA), physiologically based pharmacokinetics (PBPK), pharmacokinetic/ pharmacodynamic model (PK/PD), and population pharmacokinetics (PopPK) are introduced in the section of pharmacokinetics.

    • The Schedule of Biopharmaceutics and Pharmacokinetics Course

    Week

    Content

    1

    Introduction to Biopharmaceutics, Drug Absorption

    2

    Drug Absorption

    3

    Drug Distribution

    4

    Drug metabolism, Excretion

    5

    Introduction to Pharmacokinetics

    6

    The National Day holiday

    7

    One-Compartment Model, intravenous injection

    8

    One-Compartment Model, Extravascular Administration

    9

    Multicompartment Models andDetermination of Models

    10

    Multi-Dosage Regimen

    11

    Statistical Analysis

    12

    Bioavailability

    13

    Nonlinear Pharmacokinetics and
    Physiological Pharmacokinetic Models

    14

    Physiological Pharmacokinetic Models

    15

    PK/PD Link Models

    16

    Population Pharmacokinetic model

    17

    Population Pharmacokinetic model

    18

    Revise



  • Advanced Pharmacokinetics – Modeling and Simulation
    • Course Introduction
    • This is for Master and Ph.D. students majoring in pharmaceutical sciences, 3 credits, opens in the second semester of every school year, including a 36-hour of classroom teaching and a 36-hour of hands on modeling & simulation with software NONMEM.

      Aim: To learn and understand Pharmacokinetics, Population Pharmacokinetics, the Theory and Application of PK/PD Modeling and Simulation, and their application in Drug Research and Development and Clinical Pharmacology

      Require preparatory courses: Require preparatory courses: Anatomy, Physiology, Biochemistry, Pharmacology, Pharmaceutics, Higher Mathematics, Calculus and Statistics, and basic Biopharmaceutics and Pharmacokinetics

    • The Course Schedule of Advanced Pharmacokineticss

    Week

    Content

    Software

    2

    Biopharmaceutics

    R

    3

    Biopharmaceutics

    R

    4

    Biopharmaceutics

    R

    5

    Basic Pharmacokinetics (ADME, Compartment Model)

    R

    6

    Basic Pharmacokinetics (Modeling & Simulation)

    PsN

    7

    Non-Compartment Analysis (NCA)
    Nonlinear Pharmacokinetics (NLPK)

    PsN

    8

    Physiological Pharmacokinetics (PBPK)
    Fundamentals of Population Pharmacokinetics (PopPK)

    NONMEM

    9

    Fundamentals of Population Pharmacokinetics (PopPK)

    NONMEM

    10

    Fundamentals of NONMEM application

    NONMEM

    11

    NONMEM Application in PopPK Modeling & Simulation

    NONMEM

    12

    Pharmacokinetic/Pharmacodynamic (PK/PD) link model

    NONMEM

    13

    Pharmacokinetic/Pharmacodynamic (PK/PD) link model

    NONMEM

    14

    Application of NONMEM in PK/PD Modeling & Simulation

    NONMEM

    15

    Application of NONMEM in PK/PD Modeling & Simulation

    NONMEM

    16

    Examples of PopPK, PK/PD Modeling

    NONMEM

    17

    Examples of PopPK, PK/PD Modeling

    NONMEM

    18

    Test