Research Group

Faculty Student
        Prof. Wei Lu         Student
        Asso. Prof. Tianyan Zhou         Graduating student
        Liang Li  

Asso. Prof. Tianyan Zhou

  • Biography

  Tianyan Zhou got her Bachelor, Master and PhD degree from School of Pharmaceutical Science, Peking University in 1992, 1998 and 2006, respectively. She worked in The Hong Kong Polytechnic University as a Research Associate from Aug 2002 to Sep 2004, and studied in Oklahoma State University (USA) as a visiting scholar from Feb 2007 to Aug 2008. She is the principle investigator on Natural Science Foundation of China Grant and the Grant for the Returned Overseas Scholars of Ministry of Education. She has published more than 50 research papers and 6 book chapters. She teaches pharmaceutics, biopharmaceutics and pharmacokinetics etc. for undergraduates or graduates.
Tel/Fax: 86-10-82801717

  • Research Interests
    • Mechanism-based Pharmacokinetics/Pharmacodynamics modeling and simulation
    • Regulation mechanisms of drug metabolizing enzymes and their applications
  • Recent Publications
    1. Li, Mengyao; Li, Hanqing; Cheng, Xiaoliang; Wang, Xipei; Li, Liang; Zhou, Tianyan*, and Lu, Wei*. Preclinical Pharmacokinetic/Pharmacodynamic Models to Predict Schedule-Dependent Interaction between Erlotinib and Gemcitabine. Pharmaceutical Research. (2013), 30, 1400-1408.
    2. Zhou, Tianyan; Huang, Chaoqun; Chen, Yue; Xu, Jiaojiao; Shanbhag, Preeti Devaraya; Chen, Guangping. Methamphetamine Regulation of Sulfotransferase 1A1 and 2A1 Expression in Rat Brain Sections. Neurotoxicology. (2013), 34, 212-218.
    3. Cheng, Xiaoliang; Guo,Liping; Li, Zaiquan; Li, Liang; Zhou, Tianyan*, Lu, Wei*. A HPLC method for simultaneous determination of 5-aminoimidazole-4-carboxamide riboside and its active metabolite 5-aminoimidazole-4-carboxamide ribotide in tumor-bearing nude mice plasma and its application to pharmacokinetics study. Journal of Chromatography B. 2013, 915–916, 64–70.
    4. Zhou, Tianyan; Chen, Yue; Huang, Chaoqun; Chen, Guangping. Caffeine induction of sulfotransferases in rat liver and intestine. Journal of Applied Toxicology. (2012), 32, 804-809.
    5. Zhou, Xuan; Shang, Dewei; Zhang, Tianlan; Li, Liang; Zhou, Tianyan*; Lu, Wei*.Modeling of Angiotensin II-Angiotensin-(1-7) Counterbalance in Disease Progression in Spontaneously Hypertensive Rats Treated With/Without Perindopril. Pharmacological Research. (2012), 66, 177-184.
    6. Li, Xingang; Li, Liang; Wang, Xipei; Ren, Yupeng; Zhou, Tianyan*; Lu, Wei*. Application of Model-Based Methods to Characterize Exenatide-Loaded Double-Walled Microspheres: In Vivo Release, Pharmacokinetic/Pharmacodynamic Model, and In Vitro and In Vivo Correlation. Journal of Pharmaceutical Sciences. (2012), 101(10), 3946-3961.
    7. Xu, Jiaojiao; Chen, Ye; Li, Liang; Li, Zaiquan; Wang, Chenai; Zhou, Tianyan*, Lu, Wei*. An improved HPLC method for the quantitation of 3′-phosphoadenosine 5′-phosphate (PAP) to assay sulfotransferase enzyme activity in HepG2 cells. Journal of Pharmaceutical and Biomedical Analysis. (2012), 62, 182-186.
    8. Ji, xiwei; Chen, Ye; Li, Runtiao; Zhou, Tianyan*; Lu, Wei*. A high-sensitivity LC-MS/MS method for determination of 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3, 3-diphenylpropyl ester hydrochloride in rat plasma and its application to pharmacokinetics study. Biomedical Chromatography. (2012), 26, 1196-1201.
    9. Li, Xingang; Li, Liang; Zhou, Xuan; Chen, Ye; Ren, Yupeng; Zhou, Tianyan*; Lu, Wei*. Pharmacokinetic/pharmacodynamic studies for exenatide in diabetic rats. Acta Pharmacologica Sinica. (2012), 33, 1379-1386.
    10. Li, Liang; Li, Zaiquan; Deng, Chenhui; Ning, Miaoran; Li, Hanqing; Bi, Shanshan; Zhou, Tianyan* and Lu, Wei*. Mechanism-based Pharmacokinetic/Pharmacodynamic Model for CYP3A1/2 Induction by Dexamethasone in Rats. Acta Pharmacologica Sinica. (2012), 33, 127-136.
    11. Li, Mengyao; Wu, Qiong; Li, Hanqing; Ning, Miaoran; Chen, Ye; Li, Liang; Zhou, Tianyan*; and Lu, Wei*. A high-sensitive LC-MS/MS method to determine the concentrations of erlotinib and its active metabolite OSI-420 in BALB/c nude mice simultaneously and its application to a pharmacokinetic study. Journal of Chinese Pharmaceutical Sciences. (2012), 21, 296-303.
    12. Chen, Ye; Li, Hanqing; Xu, Jiaojiao; Jiu, Xiangfei; Deng, Chenhui; Li, Xingang; Li, Liang; Xu, Xiaoqing; Zhou, Tianyan*; and Lu, Wei*. Determination of metformin in diabetic rat plasma by an improved ion-pair high-performance liquid chromatography: Application to pharmacokinetic study, Journal of Chinese Pharmaceutical Sciences. (2012), 21, 211-218.
    13. Ning, Miaoran; Li, Liang; Li, Jian; Li, Zaiquan; Li, Runtao; Zhou, Tianyan*; Lu, Wei*. In-vitro screen of reversible and time-dependent inhibition of CYP3A by TM208 and TM209 in rat liver microsomes. Acta Pharmaceutica Sinica B. (2012), 2(2), 179–185.
    14. Shang, Dewei; Wang, Xipei; Zhao, Xiutai; Huang, Fengming; Tian, Ganzhong; Lu, Wei*; Zhou, Tianyan*. Simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat plasma using HPLC with on-line solid-phase extraction. Journal of Chromatography, B: (2011), 879(30), 3459-3464.
    15. Li, Hanqing; Li, Mengyao; Li, Zaiquan; Li, Liang; Bi, Shanshan; Deng, Chenhui; Chen, Rui; Zhou,Tianyan* and Lu, Wei*. New synthetic route of two active isomeric metabolites of erlotinib and their bioactivity studies against several tumor cell lines. Chinese Journal of Chemistry, (2011), 29(8), 1709-1714.
    16. Jiu, Xiangfei; Shang, Dewei; Chen, Ye; Li, Xingang; Wan, Xiaomeng; Zhou, Tianyan*; Lu, Wei*. A high performance liquid chromatography method for the quantitative determination assay of sitagliptin in rat plasma and its application in pharmacokinetics study. Journal of Chinese Pharmaceutical Sciences. (2011), 20(1), 63-69.
    17. Li, Liang; Li, Zaiquan; Li,Hanqing; Bi, Shanshan; Li, Bo; Xu, Jiaojiao; Zhou, Tianyan* and Lu, Wei*. Development of a quantitative real time PCR assay for absolute detection and quantification of CYP3A1 and CYP3A2 mRNA induction in rat liver. Journal of Chinese Pharmaceutical Sciences. (2011), 20(5), 597-603.
    18. Li, Haqing; Chen, Ye; Li, Zaiquan; Deng, Chenhui; Li, Liang; Bi, Shanshan; Li, Mengyao; Zhou, Tianyan*; Lu, Wei*. A high performance liquid chromatography method for the quantitative determination of erlotinib in the plasma of tumor bearing BALB/c nude mice and its application in a pharmacokinetic study. Journal of Chinese Pharmaceutical Sciences. (2011), 20(3), 245-252.
    19. Zhou, Tianyan; Huang, Chaoqun; Chen, Yue; Shanbhag, Preeti; Chen, Guangping. Methamphetamine regulation of sulfotransferases in rat liver and brain. American Journal of Pharmacology and Toxicology, (2010), 5(3), 125-132.
    20. Zhou, Tianyan; Li, Xinming; Ng, Magdeline Tao Tao; Wang, Yifan; Quek, Ngee Mien; Luo, Ji; Yuan, Weixing; Tan, Choon-Hong; Zeng, Huaqiang; Li, Tianhu. Synthesis and Characterization of Circular Structures of i-Motif Tagged with Fluoresceins. Bioconjugate Chemistry, (2009), 20(4), 644-647.
    21. Zhou, Tianyan; Wang, Yifan; Li, Xinming; Zhang, Qiang; Li, Tianhu. Synthesis and characterization of a fluorescein-labeled circular G-quadruplex. Bulletin of the Chemical Society of Japan, (2006), 79(8), 1300-1302.
    22. Zhou, Tianyan; Chen, Guoshu; Wang, Yifan; Zhang, Qiang; Yang, Ming; Li, Tianhu. Synthesis of unimolecularly circular G-quadruplexes as prospective molecular probes. Nucleic Acids Research (2004), 32(21), e173/1-e173/9.