Research: Pharmacometrics

Modeling & simulation in population pharmacokinetics (PopPK)

  • Modeling & simulation in drug development
  • Anti-tumor drugs, drugs on sexual function, anti-virus drugs, etc.

  • Clinical use of drugs - Drug monitoring software and network server in Chinese population
  • Immunosuppressants, antibiotics, psychotropic drugs, etc.

  • Model based meta-analysis (MBMA)
  • Anodynes, anti-tumor drugs, anti-virus drugs, etc.

  • Population pharmacokinetics related analysis software and tools
  • Anti-tumor drugs, cardiovascular drugs (antihypertensive drugs), hypoglycemic agents, psychotropic drugs, etc.

Modeling & simulation in pharmacokinetics/pharmacodynamics (PK/PD)

  • Mechanism based and semi-Mechanism based PK/PD model
  • Anti-tumor drugs, cardiovascular drugs (antihypertensive drugs), hypoglycemic agents, psychotropic drugs, etc.

  • PK/PD modeling based on non-continuous/counting data
  • Drugs for urinary incontinence, anaesthetics, anti-virus drugs

  • Response surface modeling in drug-drug interaction study
  • Anaesthetics, drug formulation design

Disease progression modeling & simulation

  • Animal model for tumor proliferation, diabetic, spontaneously hypertensive
  • Non small cell lung cancer, breast cancer, diabetes, spontaneously hypertension, etc.

  • Placebo effect
  • Anti-asthmatic drugs, drugs for urinary incontinence

  • The influence of circadian rhythm
  • Blood pressure, blood glucose and other biomarkers

  • The effect of Drug and Feedback regulation on disease progression
  • Hypertension, sexual dysfunction

  • PK/PD/DP link model
  • Anti-tumor drugs, anti-virus drugs, hypoglycemic agents, anti-hypertensive drugs, drugs for urinary incontinence